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Cambridge Institute (CRUK CI), to investigate the molecular mechanisms of small RNA-mediated chromatin silencing. As a whole, the Hannon laboratory has broad interests that range from discovery research
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of these factors. The work will involve genomic, proteomic and molecular approaches to decipher how these proteins contribute to NEPC and to explore if they can be therapeutically blocked. We aim to understand how
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formation, dynamics and functions of four-stranded DNA G-quadruplex structures and modified DNA bases in the genome (e.g. see Genome Biology, 2025 25, 155; Nature Chemistry, 2025, 17, 875; PNAS, 2024, 12(7
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have or expect to obtain a first or upper second-class degree in a relevant subject from a UK university, or equivalent standard abroad. Prior research experience, for instance in molecular biology
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biology, molecular biophysics, structural biology and particularly genomics. Students will contribute to one or more of our primary research areas below: Our main area of interest is on the structure and
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screens. Nature Reviews Molecular and Cell Biology 2023. 24, 477-494. Awwad, S.W., Doyle, C., Coulthard, J., Bader, A.S., Gueorguieva, N., Lam, S., Gupta, V., Belotserkovskaya, R., Tran, T-A
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understood. This project will combine molecular, cellular, and physiological approaches to explore how exercise reprograms metabolic and inflammatory pathways that connect cardiac function to systemic health
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diverse and dynamic research team working across aerospace, automotive, energy, defence, and biomedical sectors. The groups expertise includes alloy design, microstructure-property relationships, phase
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technologies, bulk and single-cell RNA-sequencing, flow cytometry, multiplex immunofluorescence, and standard molecular biology and biochemistry techniques. A computational component may also be available
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will be based at the University of Cambridge in the Department of Materials Science and Metallurgy as part of the Structural Materials Group. The Structural Materials Group is a diverse and dynamic