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Cambridge Institute (CRUK CI), to investigate the molecular mechanisms of small RNA-mediated chromatin silencing. As a whole, the Hannon laboratory has broad interests that range from discovery research
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of these factors. The work will involve genomic, proteomic and molecular approaches to decipher how these proteins contribute to NEPC and to explore if they can be therapeutically blocked. We aim to understand how
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formation, dynamics and functions of four-stranded DNA G-quadruplex structures and modified DNA bases in the genome (e.g. see Genome Biology, 2025 25, 155; Nature Chemistry, 2025, 17, 875; PNAS, 2024, 12(7
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dynamics and tissue morphogenesis during embryo development using cellular, molecular and mechanical approaches. Cell movements underlie tissue patterns and shapes. Using chick embryos as the model system