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approach combining cryo-electron microscopy, NMR spectroscopy, and advanced molecular modeling, the research will unravel the molecular architecture and conformational dynamics of pili and their interactions
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working environment that is dynamic, stimulating and welcoming. Molecular mechanisms of excitatory glycine receptors The PhD student will join Pierre Paoletti's team dedicated to the molecular and
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prerequisite (i.e., familiarity with linux, bash, conda, python). Experience in molecular dynamics simulation, protein chemistry or phylogenetics would be major assets. An interest in developing wet lab skills
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interdisciplinary research unit of Université Paris Cité, located on the Paris Rive Gauche campus. The PhD candidate will join the “Epigenetic Dynamics & Cellular Differentiation” team, led by Dr. Slimane Ait-Si-Ali
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at the SOLEIL synchrotron). The doctoral student will benefit from the dynamic environment of the team (19 people) and the I2BC institute (CNRS, CEA, Paris-Saclay University) (600 people). During cell division
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”. In: J. Chem. Phys. 158.3 (2023). [5] : Kästner, J. “Umbrella sampling”. Comp. Mol. Sc., (2011), 1(6), p. 932-942. Techniques/methods in use: Molecular dynamics, Ab-Initio Molecular Dynamics
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to these structures to cross the bacterial envelope and ensure the injection of its genome into the host. This ANR-funded project aims to unravel the molecular events and dynamics of the infection process of
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, with a dynamic international exposure animated by regular seminars and meetings. The Laboratoire de Biochimie Théorique (LBT) is internationally recognized for developing and applying computational
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of the M3i unit UPR9022 at IBMC, “Models of innate immunity in insects” at the Institute of Molecular and Cellular Biology (IBMC). Our team studies the molecular basis underlying interactions between
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, biogenesis, dynamics and its mechanism of action. The PhD student will use approaches of biochemistry, biophysics, molecular biology, proximity labeling, structural biology and fluorescence microscopy. Where