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, these investigations will assess roles of G proteins and their regulatory factors in physiological insulin secretion, and potential abnormalities in these signaling modules in beta-cell models of impaired insulin
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liver gene expression, with particular focus on cytosolic sulfotransferase family of drug- and endogenous molecule-metabolizing enzymes, in experimental models of human hepatocyte differentiation
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and activation with other biomolecules. The efficiency of these new formulations will be applied to classic models of inflammation and autoimmunity. This approach offers an innovative, scalable therapy
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and early-life development that span human cohort studies and animal models at Wayne State University in Detroit, MI. Projects comprise of multiple population-based studies including the Sperm
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behaviors from the dam. The proposed studies aim to use a translational rodent model to evaluate the effects of BUP compared to morphine on the maternal brain and behavior. Effects of gestational BUP and