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from correcting disease-causing mutations, the potential of introducing protective mutations will be explored. These strategies will be evaluated on cellular and mouse disease models, in order to
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that will be affiliated with one of six possible multidisciplinary projects. The ideal postdocs will have expertise in some of the following areas: computational modeling, computational biology, computational
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Postdoctoral Research Associate - Basic and Translational Research Training in Pediatric Classical H
classical hematology, with special emphasis on genomics, gene regulation, and cutting-edge experimental model systems and approaches to mechanistic cell and molecular biology. Trainees will greatly benefit
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basis of these tumors, which now requires systematic efforts to translate the wealth of genomic discoveries into new experimental models and therapeutic advances. Postdoctoral fellows participating in
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to respiratory viruses and T cell exhaustion during chronic infections and cancer. Ongoing studies leverage a wide array of model systems and techniques including novel mouse models of infection and cancer
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efforts dedicated to elucidating the molecular mechanisms by which platelets, immune cells, and the extracellular matrix cooperate to promote metastasis. Ongoing studies leverage a wide array of model
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the mechanisms regulating mitochondrial fission in megakaryocytes, and will use mouse models to determine how mitochondrial fission affects platelet production and function. The other project involves developing
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for a Post-Doctoral Fellow to study stem cell biology in colitis and lymphoblastic leukemia using state-of-the-art techniques such as 3D platform and respective animal models; and dissecting the molecular
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available single-cell sequencing data generated from patient samples and mouse models, we will enhance and apply machine-learning based algorithms to deconvolute bulk tumor RNA-seq samples to distinct immune
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studies by cryo-electron microscopy (cryo-EM) and/or X-ray crystallography. Perform data processing and model building (e.g., Relion , CryoSPARC , Coot, PyMOL ). Option 2 : Cell Biology Design and execute