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explored. These strategies will be evaluated on cellular and mouse disease models, in order to determine whether APP editing can reduce pathogenic effects caused by amyloid-beta. In addition to gene editing
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Schizosaccharomyces pombe as a model organism. Representative publications include: Nature (2011), PMID: 21725325; Molecular Cell (2016), PMID: 27666591; Cell Reports (2016), PMID: 26832414; PNAS (2021), PMID
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(TBI). The research will use in vitro and in vivo mouse models. Qualifications: 1). Recent PhD or equivalent degree in neuroscience, molecular biology, physiology, or cerebral vascular biology. 2
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modification. By marrying first-principles theory – trade-off analysis, game theory, reaction-diffusion, and consumer-resources models – with single-cell tracking and synthetic community experiments
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for pediatric diseases. Project Description: Our research focuses on how genetic variants contribute to diseases during early development and on developing mechanism-driven therapeutics. While animal models have
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-derived organoid models. You will work closely with in-house technology platforms, including the Single Cell Genomics Facility, Big Data Core and High Throughput Screening Facility. Our research is embedded
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Registry (SCNIR), enabling clinically driven translational research. We employ state-of-the-art experimental models to study the pathomechanism of severe congenital neutropenia and Shwachman-Diamond Syndrome
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Ph.D. or equivalent degree in mathematics, physics, computer science, bioinformatics, or a related field Experience in developing deep learning models Ideally, prior experience in analyzing biological
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experimental approaches of the laboratory include molecular-, cellular-, and immunological-based techniques along with animal models of pathogenesis and treatment. Studies are carried out in biosafety level (BSL
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on the disease mechanisms underlying inherited retinal degeneration and hearing loss, the cell biology of photoreceptors and hair cells, and potential treatments. We utilize mouse models and various approaches in