6 modelling-complexity-geocomputation PhD positions at International PhD Programme (IPP) Mainz
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nuclear export works an evolutionary conserved machinery centered on a large protein complex: TREX. While we recently uncovered a mechanistic framework of the core of this pathway, the regulatory layers
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microbes and wound healing. To carry out these diverse and complex tasks efficiently, dendritic cells have evolved into specialized subsets, each characterized by distinct phenotypic and functional
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aging in Cockayne syndrome (CS) patients. Chromatin serves as a platform for DNA repair and undergoes dynamic changes during the DNA damage response (DDR) through the Access-Repair-Restore model. Histones
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now allow us to study physically interacting cells to define a temporal interactome. In this PhD project, developing these tools in in vitro explants, in vivo models and patient samples of type 2 immune
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as well as in aging mouse models. Identification of these interactions could provide new approaches to counteract or delay age associated exhaustion of HSC. PhD Project: Contribution of cellular
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. This is because experimental techniques to solve structures of protein complexes favor more stable interactions with larger interfaces and because we lack efficient algorithms to compute similarity between