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biochemistry, genomics, molecular genetics, cell biology, and model organism systems to uncover the mechanisms by which histone mutations disrupt human development and lead to disease. Our ultimate goal is to
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repair, oxidative stress, metabolic rewiring, and immune modulation in FLASH/UHDR-RT). Preclinical model development (orthotopic murine systems, patient-derived xenografts, 3D organoids). Correlative
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Position Summary The Ornitz Lab at WashU Medicine is seeking a highly motivated postdoctoral researcher with experience working with mouse models of development and disease. Candidates will have the
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genetic mutations. We aim to advance our understanding of these diseases and to develop and translate therapeutic strategies for future clinical practice. The applicant is expected to work on mouse models
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multidisciplinary approach, spanning basic biology and translational medicine using mouse models and patient samples, tackles complex questions with profound implications for human health. Projects are available
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, to define novel biomarkers, and to identify novel therapeutical targets. We have pioneered in the integration of genetics with omic data to identify proteomic signatures and develop novel predictive models
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applicant will work closely with industry sponsors who will help to guide the project. The Elbert lab and the industry partner are interested in developing mechanistic, predictive models of neurodegenerative
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involve sensor design, including analog front-end design, light source modulation, sensor miniaturization including PCB design, sensor testing via physiology-mimicking phantoms, animal models, healthy
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. Computational and bioinformatic skills. Experience in microscopy. Generation and analysis of mouse models. Handling of human samples. Molecular biology skills including CRISPR, cloning and qPCR. In vitro cell
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their degree in the near future) in Cancer Biology or a related field. Proficiency in experimental techniques such as cell/organoid culture, library construction, imaging and handling animal models. Experience