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this field is the Integrated Stress Response (ISR), which output is orchestrated by the transcription factor ATF4. Current models, largely from C. elegans, suggest ATF4 activation is pro-longevity. However
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their dynamic, low-affinity nature and difficulties in protein purification. This project overcomes these hurdles using cutting-edge techniques: Al based computational protein modelling with AlphaFold and
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on the work of the research group. Plan your own research schedule and workload within the project schedule to ensure that the overall project milestones and objectives are met. Continuously monitor and check
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compound preparation Conduct hit-to-lead optimization and molecular modelling to identify promising lead series. Supervise and mentor students, providing guidance and support in their research activities
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(two postdoctoral researchers and two research technicians) evaluating in vitro and in vivo disease models. This post is focussed on in vitro models and delivering high quality data in assays
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, and beliefs of all. We foster a culture where everyone feels they belong and is respected. Even if your past experience doesn't match perfectly with this role's criteria, your contribution is valuable
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of Biosciences Technical Manager, and working closely with the Facilities Governance Team, you will provide specialist input into the business model and future planning for the Facility. Educated to a minimum of
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Allen and West Laboratories has uncovered an altered metabolic response to hypoxia in C9orf72 patient derived models and in Drosophila Melanogaster C9orf72 DPR models of ALS. However, the mechanisms
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to conventionally used dental resins. The study will compare the performance of biobased models with current materials, assessing accuracy of fit, surface resolution, roughness and hardness using
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and productivity. You will contribute to the macroeconomic aspect of our project, modelling the link between house prices and productivity from both an empirical and a theoretical point of view