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challenge is to decipher the heterogeneity in how dynamic fluids influence cells. Such parameters have been difficult to study, but recent advances now allow us to do so. We will combine bioimaging, modelling
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developmental incompetence and importantly, fertilised mutant oocytes generate abnormal single-pronucleus zygotes, a phenotype we recently showed is likely conserved in human. Thus, our animal model provides
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are conserved across species, including in the mouse, making the aged mouse model a useful means to understand and identify the molecular mechanisms that drive this process (doi: 10.1038/s41586-024-07238-x
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our capacity to dissect contact-dependent communication. Synthetic biology approaches, such as the engineered synNotch system, have been successfully applied in models including mouse and fly. Zebrafish
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understanding of the impact of these signals on lymphocyte function in healthy immune responses is currently limited. We have shown using in vitro models with healthy human donor cells that noradrenaline