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useful would be experience of some of the following: Generation and analysis of in vivo mouse models of cancer and infection; Neuronal tracing in in vivo models In vivo optogenetics or chemogenetics models
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cellular behaviours and generate intricate models of cell and tissue interactions. We seek enthusiastic individuals to work in an interdisciplinary lab with projects involving: • The biological aspects
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research to investigate the molecular circuits that regulate immune cell function in models of disease. The work will build on our recent breakthroughs and involve techniques such as CRISPR-screens, single
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of and ability to perform techniques relevant to the project. Experience with mouse models of neurodegenerative diseases including behavioural and molecular analyses of mouse models is essential and this
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lines, as well as embryo phenotyping. Cell culture is used to either generate genetically defined mouse lines or challenge human-relevant disease models at the Mary Lyon Centre. Mouse embryos and adult
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this challenge by investigating how cell identity is established and how it shapes the mammalian body. Our multidisciplinary approach integrates mouse developmental genetics, stem cell-based models of development
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of the following: 1) Advanced microscope working experience. 2) Working experience with rodent models. Preferable if mouse genetics and mouse colony management is involved. Track record of research: This will
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check your eligibility here: https://www.gov.uk/check-uk-visa/y Research Institute / Unit Information The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology
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Interests: Single-cell multiomics and spatial transcriptomics 3D genome architecture and nuclear organisation Epigenomics and epitranscriptomics in development and disease Model systems including human, mouse
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. Thematic Research Interests: Single-cell multiomics and spatial transcriptomics 3D genome architecture and nuclear organisation Epigenomics and epitranscriptomics in development and disease Model systems