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will involve (but not be limited to) applying sophisticated mouse genetic models of cancer and conditional gene targeting, single-cell RNA-seq, spectral flow cytometry, multiplex imaging and spatial
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sophisticated mouse genetic models of cancer and conditional gene targeting, single-cell RNA-seq, spectral flow cytometry, multiplex imaging and spatial genomics data acquisition and analysis. Where to apply E
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assays and preclinical evaluation in mouse models in collaboration with IRMB and PEPCO platform. - Analyze immune evasion, signaling, and therapeutic efficacy. - Benefit from mobility and exchange
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. To achieve our objectives, we will use cutting-edge technologies (CITE-seq, RNA-seq, Ribo-seq) and combine analysis in readily available relevant cellular models of cancer-experienced T cells, syngeneic mouse
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, RNA:protein and protein:protein interactomics) from human patients, animal models and cancer cell lines, we aim to uncover the impact of such RNA mechanisms in the development of long-term immune protection
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an internationally renowned INSERM Unit. The candidate must appreciate teamwork, have good interpersonal skills and be rigorous and organized in his/her work. Experience in molecular/cellular biology and murine models