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develop and apply advanced preclinical model systems in lymphoma—including organoids, patient-derived xenografts (PDX), and humanized mouse models—to enable functional genomic approaches and the testing
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explored. These strategies will be evaluated on cellular and mouse disease models, in order to determine whether APP editing can reduce pathogenic effects caused by amyloid-beta. In addition to gene editing
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from correcting disease-causing mutations, the potential of introducing protective mutations will be explored. These strategies will be evaluated on cellular and mouse disease models, in order to
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in live or fixed organisms, cells or tissues - Experience with data analysis in Python, R or similar - Experience working with animal models AND - Experience with mass spectrometry, including sample