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working together to understand the molecular mechanisms which regulate immune cell trafficking and function in vivo. We are especially interested in the role of integrins in immune system regulation and in
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that induce plastic cell states that are pivotal for neuronal regeneration (PMID: 34428400). The group is now exploring the underlying cellular signaling mechanisms and cell states in the CNS using genetics
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. We develop machine learning methods tailored for high-dimensional, multimodal biological data, with applications ranging from single-cell genomics to real-world clinical datasets. We are active
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Kim (DANDRITE) This project explores how mutations in chromatin-modifying genes disrupt early neurodevelopment by systematically profiling in vitro neurons using multimodal single-cell and spatial