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of these pathways. Your studies will utilize a variety of research methodologies such as human iPS cell culture and differentiation, generation of in vitro disease models, gene and protein expression analyses and
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, FACS/flow cytometry, and single cell multiomics among other assays to resolve the role of lncRNAs, such as Xist, in establishing, maintaining, and disrupting immune tolerance. The successful candidate
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circuits that regulate motivational and emotional states. The lab uses many state-of-the-art techniques, including deep-brain calcium imaging (2-photon in vivo microscopy) with single-cell resolution and
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-throughput genomic screening approaches, primary cell culture systems, and animal models of influenza disease. For more information visit https://mgm.duke.edu/faculty-and-research/primary-faculty/nicholas