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neurodevelopmental conditions, by bridging disciplines, from artificial intelligence, microelectronics, neuroengineering and nanoscience, to single-cell, imaging and molecular analysis, functional genomics and cell
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elucidation of membrane protein complexes and integrates fundamental cell biology and structural biology by cryo- electron microscopy. The lab has a strong track record in investigating scramblases and their
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data. We have developed in vivo single-cell CRISPR technologies to screen for dozens of molecular factors in vivo during developmental and disease. These technologies are a game-changer in the speed
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mimicked with in vivo models of metastasis, which provides unique opportunities to mechanistically dissect what drives the different cell states. You will link clinically relevant phenotypes to putative
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prodromal cohorts and link them to clinical readouts and α-synuclein reactivity. Use cutting-edge single-cell and immune-profiling approaches, linked to clinical phenotyping, to discover early biomarkers and
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controls to perform expression and splicing transcriptome-wide association studies (TWAS). Combined, these studies will 1) identify key dysregulated pathways in AD and FTD subgroups within specific cell