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properties, as well as distinct activation and interaction potentials and localization. Thus, type 1 dendritic cells are known to cross-present antigens and activate CD8 T cell responses, Langerhans Cells
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type 2 immune responses also contribute to the pathogenesis of allergic diseases such as asthma and atopic dermatitis. Damages of the epithelium, alarmin responses and Dendritic cell activation have all
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immunogenicity of RNA to modulate essential cell programs like cell proliferation, differentiation, and stress response. Pathological changes in the epitranscriptome are seen as a new cancer hallmark: an
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age-related conditions including cardiovascular complications, immune-aging and myeloid premalignancies. Aging of HSC results not only from acquisition of cell intrinsic insults but also from cell
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translocases have been shown to regulate R-loop levels in cells. In recent years, R-loops have been recognized as a major cell-intrinsic source of genomic instability, and dysregulation of R-loop processing is
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discriminated against all other nuclear RNAs? How does the cell ensure that only fully matured mRNAs are exported? How are faulty mRNAs and transcription byproducts targeted for degradation? At the core of mRNA