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Field
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simultaneous stimulation of these processes increases aggregate clearance. This project will employ a combination of advanced cell biology, molecular biology, live-cell imaging, and proteomics approaches. Your
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will employ techniques such as organoid cultures (pluripotent stem cell and tissue-derived), transcriptomic analyses, CRISPR-Cas engineering, and other state-of-the-art tools. Your qualifications We
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for in vivo studies. Leveraging recent advances in microscopy and voltage indicators, we can now observe voltage signaling within different compartments of a single cell in live animals, enabling us to
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include microwell arrays for 3D cell culture, as well as microfluidic organs-on-chips (OoCs) and microphysiological systems (MPSs) in various forms. The demands on these culture platforms continue to grow
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microenvironments has advanced tremendously. State-of-the-art approaches now include microwell arrays for 3D cell culture, as well as microfluidic organs-on-chips (OoCs) and microphysiological systems (MPSs) in
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organisms have been lacking. You will build on our recently developed single-cell ribosome profiling methods for C. elegans and further optimize them to apply to the early embryo. With this approach, you will
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Correct gene transcription by RNA polymerase II to generate new RNA molecules is crucial for proper cell function. However, transcription by RNA polymerases can be blocked by DNA damage on the DNA
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techniques such as organoid cultures (pluripotent stem cell and tissue-derived), transcriptomic analyses, CRISPR-Cas engineering, and other state-of-the-art tools. Your qualifications We are looking
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of this response is the cardiac fibroblast, a supportive stromal cell that plays a crucial role in the scar-forming process. While we have made significant progress in understanding the biology that separates
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recent advances in microscopy and voltage indicators, we can now observe voltage signaling within different compartments of a single cell in live animals, enabling us to examine hypotheses in a truly