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optimizations are still needed to adapt the translation of these mRNAs to the cell types of interest. As part of a collaboration with Chantal Pichon's team (University of Orleans), this project aims to use
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(erasers: FTO, ALKBH5, etc.) and m6A-binding proteins (readers: YTHDF1, YTHDC2, etc.).m6A methylation can regulate the expression of oncogenes and control cell differentiation, proliferation and migration
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mutant and transgenic reporter lines in zebrafish and mouse Participate in all the metabolomic and singe cell transcriptomic aspects of the study, from sample preparation to data analysis Perform
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of brain and other mouse tissues.•Animal experimentation, including injections, perfusion, etc.•Molecular and cellular biology experimentation (e.g., PCR, Immunoblotting, cell culture)•Maintenance
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model of the synapse between the inner hair cell and auditory nerve: Long-term adaptation with power-law dynamics,” J. Acoust. Soc. Am., vol. 126, no. 5, pp. 2390–2412, Nov. 2009, doi: 10.1121/1.3238250
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Pasteur and aims at understanding hearing from both a fundamental and clinical perspective. It combines various approaches from genetics and cell biology to biophysics and from human cognition and
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of β-1,6-glucan, a cell wall polymer, and is part of a multidisciplinary consortium comprising to other teams: Sarah Wong (Immunology of Fungal Infections, Institut Pasteur) and Lionel Ballut (Institut
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methods for single-cell data analysis (tools developed by the team : https://github.com/cantinilab ). Single-cell high-throughput sequencing, extracting huge amounts molecular data from a cell, is creating
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modulators of the α7 nicotinic acetylcholine receptor. Cell Mol Life Sci 2023;80:164. https://doi.org/10.1007/s00018-023-04779-8 . Nemecz A, Prevost MS, Menny A, Corringer P-J. Emerging Molecular Mechanisms
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. Our lab investigates the molecular and functional basis of virus-specific B-cell immune responses, with a particular focus on the role of antibodies in controlling human viral infections. Projects