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and can survive. Combining TAT and DDR inhibitors thus has the potential to convert this sub-lethal DNA damage into cancer cell killing. This project will explore the effects of radioligand therapies
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chromatin profiling methods along with CRISPR/Cas9-meduated cell line engineering and various animal models. You will study the effects of the activation or depletion of chromatin-modifying enzymes using
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We are looking for a full-time Research Assistant in Dr Fengzhu Xiong's lab at the Gurdon Institute, University of Cambridge. The successful candidate will be involved in studies of collective cell
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), e2320240121; Nature Communications, 2022, 13:142; Genome Biology, 2021, 22, 117]. We have a particular focus on the understanding of mechanisms that regulate gene expression, DNA replication and genome
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cancer is dynamic and dependent on ASCL1. Nat Cancer. 2024 Nov;5(11):1641-1659 https://pubmed.ncbi.nlm.nih.gov/39394434/ ASCL1 activates neuronal stem cell-like lineage programming through remodeling
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are part of a European consortium (https://www.elevate-dn.eu ), providing access to a community of 20 PhD students in world class institutions throughout Europe and a dedicated summer school. Candidates will
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hardware. Both projects are part of a European consortium (https://www.elevate-dn.eu ), providing access to a community of 20 PhD students in world class institutions throughout Europe and a dedicated summer