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. This project is carried out in collaboration with the Metals and Microorganisms: Biology, Chemistry and Applications team of the Biotechnologies and Cell Signaling Laboratory (BSC, UMR 7242), which develops new
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exemplified by the Janus family of kinases (JAKs) targeted by Tofacitinib both in rheumatoid arthritis in adults and in JIA [9-10]. PKs involved in upregulation of inflammation and immune response signalling
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adipose tissue. In particular, we will study the role of different membrane receptors and their signaling pathways in the browning process. The various techniques used will include cell biology and genetic
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single origin, oriC, is the key point in the cell cycle. Initiation is bidirectional. Two replicative helicases are loaded in opposite orientations on oriC. The loading of replicative helicases is
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and beyond; VHE) and producing multimessenger signals (e.g. photons and neutrinos). Indeed, the pervasive turbulence can ensure efficient stochastic particle acceleration, while the ambient backgrounds
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data available for soils of the territory considered in this study indicate total selenium levels that are rather homogeneous and classical, but nevertheless associated with transfer factors that can
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(GeV), tin-vacancy (SnV), etc.). A G4V center is a point defect in the diamond lattice, consisting of a Group-IV atom (e.g., Si) and two adjacent vacancies [2]. This defect introduces energy levels