Sort by
Refine Your Search
-
Listed
-
Category
-
Country
-
Program
-
Field
-
. SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia. Cell Death & Disease 15, 881 (2024). https://doi.org:10.1038/s41419-024-07271-8 View DetailsEmail EnquiryApply Online
-
for mitochondrial autophagy (mitophagy) induced by iron chelation drug deferiprone (DFP)(5, 6), which is under clinical trials (NCT02164253 and NCT03293069) for ALS treatment (7). This has led two questions: i) is C9
-
that cause mitochondrial damage. Accordingly, the up-regulation of mitophagy (clearance of damaged mitochondria) has been proposed as a therapeutic strategy. The Ketteler lab has recently developed novel
-
aggregation on the surfaces of mitochondria and mitophagy. At the physiological level, import dysfunction lies at the root of several neurodegenerative disorders, myopathies and systemic diseases. This project
-
Mitophagy Regulators in Metabolic reprogramming during tumorigenesis (MiRMet)" in the Autophagy group which is also part of the Centre for Cancer Cell Reprogramming (CanCell). The primary objectives
-
. The work focuses on how oxidative stress, mitochondrial dysfunction and impaired mitophagy contribute to neuronal dysfunction and degeneration across disease progression. By combining advanced molecular and
-
impaired mitophagy contribute to neuronal dysfunction and degeneration across disease progression. By combining advanced molecular and cellular assays with in vivo metabolic, ultrastructural and behavioural
-
, PD-like disorders are caused by recreational drugs or pesticides that cause mitochondrial damage. Accordingly, the up-regulation of mitophagy (clearance of damaged mitochondria) has been proposed as a
-
ubiquitylation (http://www.ppu.mrc.ac.uk/). Many world-leading researchers in the field of signal transduction have trained within the MRC PPU. The major aims of the MRC PPU are to advance understanding