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development and activation, 3) How a novel single nucleotide variant in a mitochondrial protein (Coenzyme Q6) regulates basal and inflammatory metabolic programs, and how these programs affect immune responses
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is uncovering the molecular mechanisms of ATP-dependent AAA proteolytic machines, both soluble and membrane-spanning, and their accessory factors in bacterial and mitochondrial systems. We study how
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of protein and RNA, histological analysis, mitochondrial function, and the capacity for cell growth and differentiation in culture. It also requires experience in fetal surgery for indwelling catheter
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, and blood samples Key Responsibilities:: Perform cell and molecular biology and virology experiments in HCMV-infected cells and cancer models Investigate mitochondrial function, metabolic rewiring, and
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of protein and RNA, histological analysis, mitochondrial function, and the capacity for cell growth and differentiation in culture. It also requires experience in fetal surgery for indwelling catheter
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in 2D and 3D tumor hypoxia models and its impact on cell survival and cancer therapy The impact of biological sex on mitochondrial metabolism in cardiomyocytes Transcriptional and metabolic control
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University of Massachusetts Medical School | Worcester, Massachusetts | United States | 2 months ago
Leigh syndrome, a primary mitochondrial disease, and NF2-related schwannomatosis. To learn more about our lab, please click on the link below! https://www.umassmed.edu/qlinglab/ ESSENTIAL FUNCTIONS
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the molecular mechanisms of ATP-dependent AAA proteolytic machines, both soluble and membrane-spanning, and their accessory factors in bacterial and mitochondrial systems. We study how these complexes assemble
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, PD-like disorders are caused by recreational drugs or pesticides that cause mitochondrial damage. Accordingly, the up-regulation of mitophagy (clearance of damaged mitochondria) has been proposed as a
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peroxisomes, has been proposed to play a role in the peroxisomal protein quality control system. Its relationship to bacterial and mitochondrial Lon proteases supports such a possible role. However