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mutations, mitochondrial dysfunction and chronic inflammation intersect to contribute to clinical and pathological heterogeneity in PD. The successful candidate will work at the interface of basic and
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laboratory to elucidate the effect of Abeta42 on mitochondrial liquid-liquid phase separation using live-imaging techniques. Research activities will focus on: (1) Molecular mechanism of amyotrophic lateral
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assays (IC50), and mechanism of action tests (PCR, cell cycle analysis, apoptosis/necrosis detection, GSH levels, mitochondrial membrane potential, AP sites); • experience in analyzing results
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C9orf72 is important for initiating autophagy (1), suggesting a mechanistic link between impaired autophagy and ALS pathogenesis. Intriguingly mitochondrial fission 1 protein (FIS1) is identified as a
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degradation in the nucleus. Proc. Natl. Acad. Sci. 116, 25828–25838 (2019). Decoding temporal windows for mitochondrial intervention across species using data-driven approaches Supervisor: Alberto Sanz Project
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of nutrition and health, with the aim of understanding the molecular basis of nutrition-dependent diseases, and of developing new strategies for treatment and prevention (https://www.dife.de/en/). We invite
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48 Months, Fixed Term Full-Time Post Position Summary This project, based in the Department of Anatomy and Neuroscience at University College Cork, investigates the cellular and mitochondrial
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Appointment Term: One year in the first instance with renewal possible Appointment Start Date: 05/01/2026 Group or Departmental Website: https://med.stanford.edu/genomics-of-diabetes.html (link is external) How
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mitochondrial membranes. An overwhelming majority of proteins found in the mitochondria are nuclear-encoded and are imported from the cytosol via the TOM complex using specific signals. The import pore is narrow
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: Mitochondrial Biomedicine and Theranostics Laboratory, Center for Neuroscience and Cell Biology, University of Coimbra., III- Scientific supervision/coordination of the grant: Maria Manuela Monteiro Grazina IV