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under the supervision of Dr Roman Szczesny. Mitochondria are essential organelles found in almost all eukaryotic cells. Due to the organization of human mitochondrial DNA, the regulation of individual
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). 2: High resolution, live, confocal imaging of cell death in vivo. 3: Exploring the role of mitochondria in regulating different forms of in vivo cell death by combining Drosophila’s genetics with
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of lentivirus/adenovirus/adeno-associated virus, cell transduction, cell line generation, live cell imaging, histology, microscopy, biochemical assays in cells, isolated mitochondria and tissue homogenates, PCR
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our interdisciplinary research program. Our lab investigates how bacteria and human mitochondria maintain homeostasis and respond to stress and environmental challenges. A central focus of our research
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under the supervision of Dr Roman Szczesny. Mitochondria are essential organelles found in almost all eukaryotic cells. Due to the organization of human mitochondrial DNA, the regulation of individual
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pyruvate kinase M2 maintains vascular integrity (Kim et al. JCI, 2018): https://www.jci.org/articles/view/120912 HIF2α inhibits glutaminase clustering in mitochondria to sustain growth of clear cell renal
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to damage, with a primary focus on the endolysosomal system and mitochondria? What are the protein interaction networks that make up dynamic organelles? How to familial mutations in key organellar systems
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cells. In brief, apoptosis requires mitochondria to activate proteases call caspases. Apoptosis is a silent form of cell death that fails to evoke an immune response. We have found that killing cells
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interdisciplinary research program. Our lab investigates how bacteria and human mitochondria maintain homeostasis and respond to stress and environmental challenges. A central focus of our research is uncovering
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how glial cells metabolically support neurons through dynamic transport and transfer of their mitochondria. Candidates should have educational or training experience in the biological sciences, and an