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import into mitochondria and its biological implications Principal Investigator: Dr. Barbara Uszczyńska-Ratajczak, DSc. I. Project description: Mitochondria are essential components of nearly all living
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, Y. C., Ysselstein, D. & Krainc, D. Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis. Nature 554, 382-386 (2018). https://doi.org:10.1038/nature25486 Zhao, A. et al
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research project is to characterize the folding of proteins imported into mitochondria using Electron Paramagnetic Resonance (EPR) spectroscopy. The candidate will work at the BIP laboratory (Bioénergétique
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mitochondrial membranes. An overwhelming majority of proteins found in the mitochondria are nuclear-encoded and are imported from the cytosol via the TOM complex using specific signals. The import pore is narrow
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targets have been proposed, yet, it has proven very challenging to translate these into drug development programs. Dysfunction of mitochondria is a hallmark of PD and other neuro-degenerative disorders
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, 102: 14623-14688, 2005. (https://doi.org/10.1073/pnas.0503524102) 2. N.Y. Fu et al., Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria
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. Just like mitochondria, apicoplast has its own genome and maintenance and compaction of the apicoplast DNA is essential for Plasmodium survival. Apicoplast genome is compacted by a prokaryotic histone
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us and be a part of the diverse Caltech community. Job Summary The position is for a research scientist who will study the role of cellular stress in regulating the degradation of mitochondria and
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of mitochondria is a hallmark of PD and other neuro-degenerative disorders. For instance, genetic forms of PD are caused by defects in the machinery that clears damaged mitochondria, namely Pink1 and Parkin. Also
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of the project implementation titled "Mitochondria as a therapeutic target in cancer: synthesis and biological evaluation of new triterpenic decualinium derivatives with antiproliferative effect", project code PN