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conduct directional freezing experiments coupled with confocal microscopy to study the freezing stability of soft objects. They will develop methods for the preparation and physicochemical characterization
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localization microscopy, in particular to enable dynamic observation of living cells. In particular, it has recently patented various concepts for localizing molecules under structured illumination inducing
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cultures Stable isotope labelling coupled to nanoSIMS Fluorescence microscopy & Expansion microscopy Cryo-FIB in tandem with Cryo-EM This position is financed by the Independent Research Fund Denmark
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the laboratory of Dr Charles Winterhalter, focusing on investigating DNA damage repair mechanisms during Staphylococcus aureus infection (https://www.ncl.ac.uk/medical-sciences/people/profile
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that maintain genome integrity. We are among the few labs worldwide that integrate cellular and electron microscopy techniques to investigate changes in replication fork dynamics at the single-molecule resolution
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maintaining lab functions Perform mammalian cell culture, viral transduction, and molecular cloning Apply and develop methods in protein biochemistry Utilize advanced microscopy techniques, including confocal
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of synaptic protein complexes at near-atomic resolution by cutting-edge technologies cryo-electron microscopy and tomography (cryoEM/ET), and other biochemical and biophysical approaches. This role of person
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experiments using routine cellular, molecular biology, and protein chemistry procedures. These routine lab procedures include microscopy, histology, immunohistochemistry, immunofluorescence, ELISA, Western blot
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. Areas included are hematology, immunology, bacteriology, chemistry, serology, and microscopy. Commands knowledge of laboratory information system. Functions in areas of specimen handling and processing
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approach combining cryo-electron microscopy, NMR spectroscopy, and advanced molecular modeling, the research will unravel the molecular architecture and conformational dynamics of pili and their interactions