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characterization using cryo-electron tomography (cryo-ET), and complementary light microscopy methods. Specific objectives are: Setting up cryo-ET FIB SEM workflow for reconstituted synapses Visualize nanoscale
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the detachment process. To achieve this goal, the project will use a dedicated in-situ scratch tester with in-situ scanning electron microscopy observation capabilities, which so far was used for indentation
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supports and training in advanced light and fluorescent microscopy. Dr. Ernest van der Wee will work closely with us supporting the development of our microscopy system. Our group works closely and shares
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) spectroscopy and microscopy techniques to develop structure-performance relationships and understand, for example, the function and deactivation of solid catalysts. The group consists of two full professors, one
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study single biomolecules rely on fluorescence microscopy. Recent advances in Zijlstra’s group used metallic nanoparticles to enhance the fluorescence intensity (link). This approach has given access
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of larval zebrafish. Data analysis: analyze whole‑brain calcium imaging recordings. Spatially resolved molecular methods: apply expansion microscopy (ExM) adapted for spatial transcriptomics to identify
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mouse handling are required. Familiarity with microscopy and/or molecular or cell biological techniques are strengths. The candidate needs to have good writing and presenting skills (in English). Where
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, you will isolate these membrane complexes from different genetic backgrounds, characterize their biochemical properties and analyse their molecular structure using cryo-electron microscopy (cryo-EM
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: collaborate with the group of Dr Arnold Boersma at the Bijvoet Centre to develop novel sensors for measuring macromolecular crowding in C. elegans; use advanced fluorescence microscopy techniques, complemented
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metasurfaces to boost the sensitivity of plasmonic biosensors. Introduction Current workhorse techniques to detect and study single biomolecules rely on fluorescence microscopy. Recent advances in Zijlstra’s