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establish and validate microfluidic co-culture systems using human glomerular cells and benchmark these platforms against human kidney multi-omic and spatial datasets. These systems will be further developed
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microfluidics channels experimentally. The particle dynamics under solute concentration gradient will be analyzed and new methods of manipulating particles in complex geometries will be developed. Application
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obesity. Nat Med, doi:10.1038/s41591-023-02343-2 (2023). Fischer, K. et al. Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells. Nat
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work is to identify new therapeutic targets that can inform drug development for ALS/FTD. Laboratory work will involve differentiations of human iPSCs to motor neurons, developing microfluidic and
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space and time: with help of microfluidic soil chips and an advanced access system for microscopy and spectroscopy we will access natural soil microbial communities to answer questions about their
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on developing a microfluidic technology for loading molecules and nanoparticles into red blood cells ex vivo, with the goal of leveraging red blood cells as a biocompatible drug depot for extended release. The
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on developing a microfluidic technology for loading molecules and nanoparticles into red blood cells ex vivo, with the goal of leveraging red blood cells as a biocompatible drug depot for extended release. The
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changes in microgravity conditions. d. Ability to perform cell culture and tissue models such as 3D tissue models and microfluidic systems to simulate microgravity. e. Understanding and experience with
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cells and microfluidics to generate mature and functional vascular tissues. This work will be completed as part of our multidisciplinary team studying the interactions between cells and their
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of chromatin or obstacles on the DNA. To do so, you will design and employ novel biophysical instrumentation (e.g. optical tweezers, single-molecule fluorescence, microfluidics, cryo-electron microscopy) and