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establish and validate microfluidic co-culture systems using human glomerular cells and benchmark these platforms against human kidney multi-omic and spatial datasets. These systems will be further developed
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obesity. Nat Med, doi:10.1038/s41591-023-02343-2 (2023). Fischer, K. et al. Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells. Nat
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work is to identify new therapeutic targets that can inform drug development for ALS/FTD. Laboratory work will involve differentiations of human iPSCs to motor neurons, developing microfluidic and
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microfluidic technology In vivo expertise recommended Experience with cell culture techniques including primary endothelial cells Experience in expression and purification of proteins Experience with molecular
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of chromatin or obstacles on the DNA. To do so, you will design and employ novel biophysical instrumentation (e.g. optical tweezers, single-molecule fluorescence, microfluidics, cryo-electron microscopy) and