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responses in the context of inflammatory bowel disease and other mucosal barrier disorders. A central aim will be to define the mechanisms by which metabolites such as butyrate shape antimicrobial programmes
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mechanisms by which co-inhibitory receptors, including PD-1, BTLA, TIGIT, and CD200R, regulate T cell function in autoimmune settings. Despite sharing common downstream signalling components such as SHP1 and
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of synaptic inhibition and plasticity in the mammalian cortex. The research will employ studies in rodents, in order to characterize novel mechanisms by which synaptic efficacy changes as a function of the
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, in order to characterize novel mechanisms by which synaptic efficacy changes as a function of the animal’s recent experience. You should be an enthusiastic, motivated and highly organised scientist
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are seeking a motivated Postdoctoral Associate with an interest in primary headache disorders and related co-morbid conditions to help uncover novel disease mechanisms that can lead to the development of novel
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excellence that has a strong focus on understanding the molecular mechanisms of disease, with the aim of translating basic discoveries to clinically meaningful therapies. It is known for its positive research
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narrative level. This stands in marked contrast to biological mechanisms which are addressed directly, empirically, and statistically. The reason is that we know how to test hypotheses about mechanisms but
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to characterize the epignetic landscapre of MPN and sAML, uncover the molecular mechanisms underlying disease progression and treatment resistance and identify novel therapeutic targets. You will take a lead on
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About the role The Lu lab is interested in the mechanism by which cancer karyotype mutates and becomes resistant to therapy, with the aim of finding new ways to treat cancer more effectively. We
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to biological mechanisms which are addressed directly, empirically, and statistically. The reason is that we know how to test hypotheses about mechanisms but no similar method currently exists for purpose. Our