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-acquired infections and large-scale industrial problems such as clogging oil pipes and slowing down cruise ships. One of the key hallmarks of a biofilm is the extracellular matrix (ECM), which is secreted by
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intrinsic insults but also from cell extrinsic effects. Within the bone marrow (BM), HSC interact with several cellular and acellular (growth factors, extracellular matrix and vesicles) components which have
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