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successful candidate, you will: This project with Dr. Nagarajan Vaidehi involves developing and application of interpretable machine learning methods to uncover allosteric regulation of disordered regions in
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between CAR T-cells and the bone marrow microenvironment. This project will use spectral flow cytometry, in vitro and in vivo CAR T-cell assays and gene knockdown, overexpression, and CRISPR knockout
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Hope. To accelerate the development of new therapies, we leverage City of Hope’s unique in-house GMP manufacturing capabilities for cell therapy (CAR-T cells, stem cells, etc.), monoclonal antibodies
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. This project involves the development and application of interpretable machine learning methods to uncover allosteric regulation of disordered regions in the dynamics of G-protein coupled receptors to enable
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Medicine, and member of the City of Hope Comprehensive Cancer. The Perry laboratory uses structural biology approaches, together with small molecule and fragment-based drug discovery, computer-aided drug
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on understanding how tumor cells evade immune surveillance. The lab is particularly interested in: The regulation of natural killer (NK) cell development, function, and anti-tumor activity. CAR-NK cell therapy
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, glioblastomas, colon cancer, and lung cancer. Advancing precision oncology through machine-learning models: We integrate multimodal patient data, including multiomic data and health record information, to develop
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marrow transplantation and CAR T cell therapies, spanning basic science to clinical trials. For more information about Dr. van den Brink’s research, please visithere. Lab's Philosophy : We foster a
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of induced pluripotent stem cell-based human disease models 2) Understanding the role of immunity during tumorigenesis as well as disease relapses in order to design novel inhibitors, CAR-T cell therapy and