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/Statistics, Medical/Health Informatics. Strong computational and programming skills with abilities to develop cutting-edge large-scale machine/deep learning algorithms using high-performance computing (HPC
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approach to develop chemical probes, investigate biological mechanisms, and evaluate in vivo efficacy. In particular we use the promiscuous pregnane X receptor (PXR) and constitutive androstane receptor (CAR
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. In particular we use the promiscuous pregnane X receptor (PXR) and constitutive androstane receptor (CAR) as models. PXR and CAR transcriptionally regulate cytochrome P450 3A4 (CYP3A4) and CYP3A5-drug
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, enhanced by machine-learning and data-driven analysis techniques. Additionally, the study will encompass electrically triggered events that mimic the voltage-based signaling of biological synapses