Postdoctoral Scholar in Vascular Mechanobiology and Inflammation at UCLA and Doheny Eye Institute

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Posted: Unknown

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Posted: 12-Jul-25

Location: Los Angeles, California

Type: Full-time

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Research - Laboratory/Non-Laboratory
Staff/Administrative

Internal Number: 6376066

Postdoctoral Scholar in Vascular Mechanobiology and Inflammation at UCLA and Doheny Eye Institute
University of California Los Angeles
Requisition Number: JPF10491
Postdoctoral Position in Vascular Mechanobiology and Inflammation at UCLA and Doheny Eye Institute
A postdoctoral position in the mechanobiology of vascular inflammation is available in the laboratory of Professor Kaustabh Ghosh at UCLA and Doheny Eye Institute. With funding from the NIH and private foundations, the Ghosh Research Group is committed to developing effective therapies for vision-threatening vascular defects in the eye.
Job Description
This position will focus on the early stages of diabetic retinopathy (DR), a major microvascular and vision-threatening complication of diabetes. Currently, DR is clinically managed only in its advanced stage that is marked by excessive multiplication and leakiness of blood vessels in the inner retina. However, there is growing recognition that more effective treatment of DR is possible by tackling it in the early stages when the retinal blood vessels degenerate.
The Ghosh Lab is taking a multidisciplinary approach to understand and prevent this early loss of retinal vessels in diabetes. Integrating the principles of vascular biology, mechanobiology, inflammation, and bioengineering, their work has introduced a new paradigm that implicates vascular stiffness' as a crucial determinant of vascular degeneration associated with early DR. Their ongoing studies aim to identify the factors that alter vascular stiffness in the eye and uncover the mechanobiological mechanisms by which altered stiffness causes vascular loss in diabetes. These studies, funded by the National Eye Institute/NIH and private foundations, have the potential to identify new classes of drugs that restore normal vascular stiffness and function in the eye and thereby block DR progression in their early stages.
To drive this innovative research forward, we are looking for motivated individuals to perform multidisciplinary research involving animal and cell culture models of DR, and principles and techniques related to vascular biology, mechanobiology, and inflammation.
Requirements

• Candidates must be a recent (or soon-to-be) Ph.D. graduate or a junior postdoctoral fellow in biomedical sciences/engineering, or related field.
• The successful applicant will have a strong research background in cell/molecular biology and biochemistry, and a record of first-authored publications.
• Previous experience with mammalian cell culture, fluorescence microscopy, flow cytometry, PCR, immunoblotting, and immunohistochemistry is desirable.

Environment
UCLA is an elite research university that is part of the prestigious University of California system. U.S. News & World Report has consistently ranked UCLA's Department of Ophthalmology and Doheny Eye Institute among the top 5 in the nation for vision research and care. U.S. News & World Report also ranked UCLA 13th among all universities in the world (2025 Global Ranking). State-of-the-art facilities for proteomics, genomics, transgenic mice, retinal imaging and functional assessment, cellular mechanobiology, confocal imaging, and flow cytometry are all available for the project.
To apply, please visit: https://recruit.apo.ucla.edu/JPF10491
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy, https://policy.ucop.edu/doc/4000376/DiscHarassAffirmAction
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UCLA is known worldwide for the breadth and quality of its academic, research, health care, cultural, continuing education and athletic programs. UCLA offers undergraduate degrees in more than 127 majors and graduate degrees in 198 program areas. UCLA has 11 highly regarded professional schools. Eight are ranked among the nation's top 15 in their field by U.S. News & World Report. UCLA is consistently among the most popular campus in the nation for undergraduate applicants. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, national origin, disability, or protected veteran status. Benefits:UCLA offers a comprehensive benefits package, including an average of three weeks' vacation per year; an average of 12 days per year sick leave; 13 paid holidays per year; health, dental and optical benefits; life insurance; disability insurance; the University of California Retirement Plan with 5 year vesting and various voluntary UC Savings Plans. There are also special programs and privileges available, such as accessibility to cultural and recreational programs, athletic events, and the University Credit Union.
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