Postdoctoral Research Associate: Chromosomal instability in marine transmissible cancers (fixed-term)

An exciting new opportunity for a Postdoctoral Research Associate has become available within the Bivalve Transmissible Neoplasia Group (www.zoo.cam.ac.uk/btn ), a newly-established small, interactive and international research team based at the Department of Zoology, with strong collaborative links with other groups in Cambridge and beyond. The group's research is focused on the genetics and evolution of a recently discovered family of clonally transmissible cancers which affect several species of marine bivalves.

This new position is part of an ERC-funded project examining genome evolution in hundreds of samples from multiple independent marine transmissible cancer clones. The role provides an exciting opportunity to combine single-cell cancer genomics with molecular cytogenetics and statistical modelling to study the causes and consequences of extreme chromosomal instability in these cancers.

The role will involve: - Learning and applying cytogenetic methods for generation and analysis of chromosome imaging data - Developing new methods for inference of copy number alterations from single-cell DNA sequencing data - Analysing patterns of single-cell copy number variation to identify mechanistic signatures of chromosomal instability - Interacting with international experts in molecular cytogenetics, single-cell sequencing, somatic evolution, and comparative cancer genomics - Possible scope for field work involving marine bivalves.

The ideal candidate will be self-motivated, passionate about cancer genome biology and somatic evolution, and willing to learn, develop and apply state-of-the-art molecular and computational approaches. They will hold a PhD in a relevant subject, have a solid computational background, and be able to curate, analyse and interpret complex single-cell data sets. Experience in molecular biology, cytogenetics or histopathology is desirable.

Please refer to the Further Particulars for more information.

Fixed-term: The funds for this post are available for 2 years, with a possibility of extension subject to project status and funding.

Flexible working requests will be considered.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

If you have any queries regarding the application process please contact Anastasia Nezhentseva.

Email: an286@cam.ac.uk Telephone: (0)1223 330117

Please quote reference PF45896 on your application and in any correspondence about this vacancy.

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