Postdoctoral Researcher in NeuroMetabolic Disease Modeling

The successful candidate will join the Enzymology & Metabolism group, led by Prof. Carole Linster, which deciphers the cellular metabolism in rare and more common neurodegenerative or neurometabolic diseases. We exploit genomic and post-genomic data to fill gaps in metabolic networks, discover new enzyme functions, and elucidate their role in disease. For more information, please visit our website. The open position is part of the NAXDivo Core project, funded by the Fonds National de la Recherche (FNR), which aims at generating and analyzing whole organism models (zebrafish and mouse) to dissect the pathophysiology of a recently identified rare pediatric neurometabolic disorder. The approach involves mainly deep longitudinal phenotyping at the transcriptome, metabolome, and brain morphology levels. The successful candidate will work in close collaboration with the LCSB core facilities, as well as the Skupin and Heneka groups.

Main tasks:

• Generate mutant and transgenic reporter lines in zebrafish and mouse
• Participate in all the metabolomic and singe cell transcriptomic aspects of the study, from sample preparation to data analysis
• Perform behavioral assays in the animal models
• Immunohistochemical analysis of neuronal, astroglial and microglial markers in zebrafish and mouse brain samples
• In vivo imaging of specific brain cells in the transgenic zebrafish and mouse lines
• Develop phenotypic rescue assays, based on selected readouts, in the generated disease models to test small molecule drug candidates
• Modern data management and precise project documentation
• Work in a collaborative environment, also with different service-based core platforms (animal, sequencing, metabolomics, and imaging facilities)
• Active participation in group meetings
• Independent drafting of ethics proposal, project reports and grant applications
• Write manuscripts for publication in peer-reviewed scientific journals as well as present research findings at international scientific meetings

For further information, please contact Assoc. Prof. Carole Linster (email address: carole.linster@uni.lu ).