Master Thesis - Development of ligand conjugated lipid nanoparticles for targeted T cell delivery...

Diploma & Master Thesis

Master Thesis - Development of ligand conjugated lipid nanoparticles for targeted T cell delivery (f/m/x)

102778

Full time
39 hrs./week

Neuherberg near Munich

At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we accelerate the transfer of new ideas from the lab to real-life applications, improving lives.

The

Institute for Intelligent Biotechnologies (iBIO)

develops and implements tools to analyze biological samples' 3D structure and molecular identity. At iBIO, we bring together cutting-edge science from biology, chemistry, engineering, and computer applications. Our overarching aim is to obtain a holistic view of interconnected biological systems in health and disease. We develop clearing technologies for cellular-level imaging and deep learning algorithms (AI) to analyze large imaging and molecular data in a robust and unbiased way. Worldwide media, including New York Times, Wall Street Journal, and Süddeutsche Zeitung, have highlighted our research. You can find out more about us here

. We are offering an exciting Master’s thesis project for a motivated student (f/m/x). You will prepare lipid nanoparticles carrying targeting ligands for enhanced cell specificity and and work with lipid nanoparticles carrying targeting ligands for enhanced cell specificity.

Your tasks

• Optimization of the targeting ligand conjugation to nanoparticle surface (conjugation chemistry parameters, purification methods)
• Characterization of the nanoparticles (DLS, zeta potential, encapsulation efficiency, attachment efficiency)
• In vitro functionality assessment (cytotoxicity, cellular uptake, delivery and expression efficiency, cell specificity)

Your profile

• Enrolled in a Master's program
• Basic biochemistry knowledge and experience with laboratory work
• Theoretical knowledge about nanoparticles and nucleic acid delivery
• Experience with conjugation techniques, lipid nanoparticles, and cell culture is a plus
• Structured work style and the ability to work in a team are required

This position has a fixed term, depending on the requirements of your study program.

Managing Directors Matthias Tschöp and Mike Frieser: „We believe that diversity is the key to groundbreaking research and innovative solutions. Our flexible working models and remote options create a supportive environment for balancing work and family life. For us, contributing to a healthier society in such an inspiring workplace is truly meaningful.“

Get to know us

Interested in applying?

If you have any questions, feel free to contact Stefanie Reitinger, stefanie.reitinger@helmholtz-munich.de, who will be happy to help.

Our recruiting is decentralized - your application will be reviewed directly by the specialist department in which you could work in the future.

More information about our application process

Please send your application only via our online application tool and with the following documents:

• CV
• Cover letter
• Degrees/Diplomas/Certificates

If you have obtained a university degree abroad, we will require further documents from you regarding the comparability of your degree.

Please request the Statement of Comparability for Foreign Higher Education Qualifications as early as possible.

We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference.

Learn more about diversity at Helmholtz Munich

Our commitment

Helmholtz Munich
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute for Intelligent Biotechnologies
Ingolstädter Landstraße 1
85764 Neuherberg

This research center is part of the Helmholtz Association of German Research Centers. With more than 42,000 employees and an annual budget of over € 5 billion, the Helmholtz Association is Germany's largest scientific organisation.