CEA-Saclay, Institut de Physique Theorique
Position ID:
CEA-Saclay -IPhT -SELMOD2025 [#30189]
Position Title:
Position Location:
Gif sur Yvette, Ile de France 91191, France [map ]
Subject Area:
Statistical Physics / Statistical Physics
Appl Deadline:
2026/02/28 11:59PM * (posted 2025/06/29, listed until 2026/02/28)
Position Description:
Apply
Position Description
A 1 year postdoctoral position is available to work on computational models of artificial evolution for aptamer design, expected to start between November 2025 and February 2026.
Aptamers are often obtained through rounds of in vitro competitive selection (SELEX), starting from artificial libraries of large numbers (~10^15) of distinct sequences. When the experiment succeeds, variants that perform the selected function well are enriched from one round to the next, and eventually the library collapses to a few selected functional aptamers. The evolution can be tracked in detail by deep sequencing of the successive rounds. The goal of the project is to exploit such data to develop generative models for aptamer design.
The candidate is expected to have a strong background in machine learning and statistical physics, with a real interest for interdisciplinary research and computational biology in particular.
The fellow will join my team at IPhT, in Paris-Saclay. The IPhT is located just outside of Paris in picturesque Gif-sur-Yvette at the French CEA and Université Paris-Saclay. Free shuttle buses and transit-pass discounts are provided for researchers who wish to live in downtown Paris. Hybrid work options (partially remote) are possible. This work will be carried out in close collaboration with the experimental team of Frédéric Ducongé, MIRCen, at the Institut de Biologie François Jacob of CEA.
Applications should contain:
- your CV
- a brief summary of your past research (less than half a page)
- a brief statement of research interests (less than half a page)
- a brief cover letter (less than half a page) * publication list * 2 letters of recommendation should be emailed independently
Please upload the required documents through the AcademicJobs online interface.
Application Materials Required:
Further Info:
https://sites.google.com/view/jorgefdcd/open-positions
Institut de Physique Théorique
CEA Saclay
91191 Gif sur Yvette
France