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pocket to reduce ligand's binding affinity ( Proc Natl Acad Sci U S A . 120: e2217804120, 2023 ); and discovered the first CYP3A5-selective inhibitor and its structural basis ( J Am Chem Soc 143:18467
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pathways by HSV-1 UL12.5 for reactivation from latent infection. Krakowiak PA et al Proc Natl Acad Sci U S A. 2025 Jan 28;122(4):e2413965122.doi: 10.1073/pnas.2413965122 . Single-genome analysis reveals a
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with stress, but few other generalities have emerged, in part because, researchers across diverse fields—from cell biology to genomics, agriculture, cancer, and ecology—rarely interact. Through
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, Cleveland, Ohio, USA. Our research focuses on the basic molecular mechanisms underlying cancer invasion and metastasis as well as interactions within the tumor microenvironment in major solid tumor cancers