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. Our research focuses on bacterial and viral pathogens, their interaction with the human immune system and new effective substances and vaccines. The department Mechanochemistry of Inflammation aims
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spectrometry • Interact with collaboration partners (Alexander Grünberger, Bielefeld University; Vasily Zaburdaev, Friedrich-Alexander Universität Erlangen-Nürnberg; Knut Drescher, University of Basel
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immunity. However, the detailed interactions between involved vs bystander cells and the resulting activation and induction of type 2 immune responses are incompletely understood. Thus, treatment approaches
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spectrometry • Interact with collaboration partners (Alexander Grünberger, Bielefeld University; Vasily Zaburdaev, Friedrich-Alexander Universität Erlangen-Nürnberg; Knut Drescher, University of Basel
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and their interactions with the immune system, while also investigating new compounds with potential therapeutic effects. The department VIRI studies viral infections in animal models and in models
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: Protein-protein interactions (PPIs) are important mediators of most cellular processes. Understanding how proteins interact with each other, ideally at structural resolution, is key in understanding
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the molecular mechanisms modulating genome maintenance pathways in the cell. The Beli group has expertise in quantitative proteomics approaches in analyzing protein interactions and regulation on chromatin
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, host takeover, and anti-phage defense. Due to their comparably small genomes, RNA phages must co-opt bacterial host factors to successfully replicate. While some of these interactions have been
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characterized by distinct phenotypic and functional properties, as well as distinct activation and interaction potentials and localization. Thus, type 1 dendritic cells are known to cross-present antigens and
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molecular mechanisms for altered interaction that affects HSC output in aging. This will be achieved via the implementation of state of the art multicolor flow cytometry analyses, imaging, omics techniques (e