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. Additionally, the impact of bioprocessing of niacin will be examined, and the bioaccessibility of niacin in different food products will be assessed using a static in vitro digestion model. The research is
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of the Desulfovibrionaceae and their interactions with the host and the wider gut microbiome. Our work uses a range of advanced host-relevant experimental systems, including in vitro and in vivo models, integrated with
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bioaccessibility in vitro. The research is expected to yield new information on choline in plant-based foods, promoting the adoption of nutrition recommendations. Throughout the project, you will collaborate with
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; Professional rigour and good teamwork skills; Verbal communication skills and fluency in Portuguese and English. Work plan: Participation in all activities of the APTA4shiga project, including: In vitro
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computer tools / IT skills Specific Requirements Contribute to the team's shared tasks Manage mouse model colonies within the center’s animal facility Develop functional assays both in vivo and in vitro
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will use genetic perturbation and overexpression in vitro and in vivo (mouse) models to uncover principles that inform tissue repair, oral health, and host–microbe interactions. This position offers
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management. Responsibilities: 1. Structure-guided engineering and optimization of novel proteins 2. Extensive characterization of proteins both in vitro and in vivo, including Cryo-EM 3. The use of advanced
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is focused on uncovering the role of the RNA binding protein Tra2β in normal brain development and how this goes wrong in a neurodevelopmental syndrome called TRA2B syndrome. We will use both in vitro
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in vitro viability assays and clonogenic survival assays. • Prepare cell culture media, reagents, chemical solutions, and assist in developing new laboratory procedures. Animal Work & Experimental
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the Gram-positive bacterium Enterococus faecalis using a combination of in vitro, in vivo, and computational approaches. We need additional research support carrying out experiments and analyzing data