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: Cellular and Molecular Medicine Description: Interested in Neural Stem Cells (NSCs) physiology and function? Want to monitor NSCs activation and division using in vivo live imaging approaches in behaving
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amyotrophic lateral sclerosis (ALS). Projects will involve gut microbiota manipulation and in vivo multiphoton imaging of the brain using animal models of ALS. The desired candidate will have experience in
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-density electrophysiological recording systems, two-photon imaging, optogenetics, transgenic mouse lines for targeting specific neuronal subtypes, and behavioral rigs. We strongly encourage candidates
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combining chronic in vivo imaging (two-photon microscopy, fiber photometry, GRIN lens imaging) with genetic and molecular approaches to dissect how cell type- and projection-specific plasticity orchestrate
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dynamics in models of brain injury and neurodegeneration (amyotrophic lateral sclerosis / ALS and Alzheimer’s disease / AD). Projects will involve in vivo multiphoton imaging of glia, vascular, perivascular
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at MUN features state-of-the-art medical laboratories equipped with high-resolution confocal imaging, a Seahorse analyzer for metabolic profiling, flow sorters and cytometers, an electron microscopy suite