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interaction that affects HSC output in aging. This will be achieved via the implementation of state of the art multicolor flow cytometry analyses, imaging, omics techniques (e. g. single cell sequencing and
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step in eukaryotic gene expression, ensuring that mature transcripts are delivered from the nucleus to the cytoplasm for translation. Multiple challenges are faced in this process: How are mRNAs
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) are important mediators of most cellular processes. Understanding how proteins interact with each other, ideally at structural resolution, is key in understanding molecular processes, how disease mutations would
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translocases have been shown to regulate R-loop levels in cells. In recent years, R-loops have been recognized as a major cell-intrinsic source of genomic instability, and dysregulation of R-loop processing is
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longer-term immune responses. Specifically, they play key roles in pathogen recognition, antigen uptake, processing and presentation, but also contribute to tissue homeostasis, tolerance to commensal