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together I) microfluidic/flow-based nanoparticle synthesis, which underpins modern nanoparticle drug delivery systems including the Pfizer–BioNTech COVID-19 vaccine, together with II) high-throughput
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). While mRNA vaccines have demonstrated rapid development and high efficacy, current formulations primarily protect against severe disease rather than preventing infection at mucosal entry points
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transformations at such interfaces, and how they are influenced by external electric fields and electrolyte composition. Access to high performance computing facilities including GPU clusters will be provided
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targeting AMR gene suppression AI-driven genome design: Use LLM tools (e.g. PlasmidGPT, Evo2) to refactor plasmid genomes for enhanced manufacturability, safety, and performance Microbial validation: Test
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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
conditions and characterise the dynamic range and sensitivity of the nanopore sensors Develop multiplexing strategies for simultaneous detection of multiple antibiotic classes Perform proof-of-principle
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and a disulfide-rich knob mini-domain, enabling high stability and independent folding. Despite their promise, the structural and functional diversity of UL-CDRs remains largely unexplored. This project
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their pandemic potential and classification as bioweapons. This project aims to develop a machine learning-accelerated NMR platform for the discovery of high-affinity inhibitors targeting viral RNAPs. Building
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Scientific communication and translational research Opportunities include presenting at international conferences, publishing in high-impact journals, and collaborating across UCL and with external partners
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) alter resistance mechanisms. Use high-throughput screening and biofilm models to identify conditions that reduce multidrug resistance (MDR). Build a systems-level understanding of how these mechanisms
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platforms, and regulatory guidance Evaluate long-term performance and potential for clinical translation Impact and Outlook: This project addresses a critical unmet need in orthopaedic surgery by developing