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algorithms will turn these high-resolution insights into searchable, verifiable databases, seeking to better inform assay decision making. Applicants should have (or expect to be awarded) a good UK Master's
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" (Supervisor: Prof Timothy O'Leary) uses principles from systems neuroscience to develop reliable, low-power spiking neural networks and learning algorithms for implementation in a new generation of neuromorphic
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learning, evidence synthesis in public health and statistical genetics and genomics. We are recognised for our strength in Bayesian inference applied to biomedicine and public health. The MRC Biostatistics
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, ¿-ray), demonstrated that genetic backgrounds influence radiation therapy (RT) responses, with DNA-damage response (DDR) pathways critically involved. However, determinants of sensitivity to high-LET
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tumours and metastases with the goal to design combinatorial therapeutic approaches. The project will involve the use of genetically complex organoid-derived transplantation mouse models of pancreatic
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. References/further reading Czech B, et al. (2018). piRNA-Guided Genome Defense: From Biogenesis to Silencing. Annual Review of Genetics. Van Lopik J, et al. (2023). Unistrand piRNA clusters are an evolutionary
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details Our lab exploits both chemistry and biology to address fundamental mechanisms of genome function. While many genetic determinants of cancer are known, alternative nucleic acid secondary structures
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-consuming and often fail to express target proteins at sufficient levels. In this project, you will investigate whether mammalian cell lines can be genetically altered to enhance expression of challenging
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endocrine response. Nat Genet. 2011 Jan;43(1):27-33. https://pubmed.ncbi.nlm.nih.gov/21151129/ Pioneer transcription factors: establishing competence for gene expression. Genes Dev. 2011 Nov 1;25(21):2227-41