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aim to decipher how genetic and epigenetic information is processed into different gene expression programs. The Baubec lab external link takes a systems biology approach to understand the role
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the course of the disease (PDD). Mutations in GBA1 and LRRK2 are the most common genetic risk factors. Up to 80% of cases are genetically sporadic. Although many upstream pathways may cause PD, the downstream
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work to discover cell specific isoforms and relate them to pathological signatures and genetic risk factors in ALS patient tissue. You will apply supervised and unsupervised machine learning methods
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, mammalian cell culture and genetic perturbation techniques, live cell microscopy and quantitative image analysis. Additional Information Benefits We will give you a temporary employment contract of 2 years
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. From forest fires to big data, from obesity to malnutrition, from helium to the universe and from genetics to medicine: our education and research cover the full breadth of science, from molecules
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of genetic diversity. You will model how these effects propagate across ecosystems and scale up to larger geographical regions, while accounting for multiple environmental stressors. We are looking for a
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will be then established using animal free culture media and will be genetically modified with bioluminescent reporters for OA endotype in vitro modelling. These modified cells will be used to establish
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of functional glycans in situ and development of advanced infection model systems to study the role of functional receptors. These models will include (genetically engineered) stem cell-derived 2D and 3D
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– often falters when beneficial traits are genetically linked to deleterious ones, a phenomenon known as linkage drag. To overcome this bottleneck, we are launching a transformative project that leverages
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Maintaining the integrity of our genome is essential to preventing genetic diseases such as cancer. While it is well known that DNA damage can compromise this integrity, recent research shows