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pharmacologically tractable. The project combines genetic (CRISPR/Cas9) and chemical (small molecule inhibitors, probes) tools to modulate the pathway and study its effects on adipocyte function. A successful
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Genome maintenance pathways are crucial to preventing genetic diseases such as cancer. Major progress has been made in our understanding how DNA damage is repaired. Yet, even in the absence
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change, we need to know the amount of genetic variation in egg development time. However, we know little about the mechanisms underlying the temperature sensitivity of egg developmental time and to what
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services to horses and companion animals, and both clinical and more fundamental research in the areas of regenerative medicine, locomotion, genetics and reproduction. More information For more information
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matrix, and the signalling pathways that mediate communication with cardiac parenchymal cells. You will employ in vitro and in vivo platforms based on the spiny mouse, combined with genetic tools
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stress on ageing. In particular, we will estimate genotype-by-age effects on sociality, investigate the genetic architecture of sociality (e.g. GWAS and regional heritability), estimate selection
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. Research in our group aims at advancing fundamental knowledge of the interactions between plants and their pathogens, using state-of-the-art methods in molecular biology, genetics, biochemistry, and
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on ageing. In particular, we will estimate genotype-by-age effects on sociality, investigate the genetic architecture of sociality (e.g. GWAS and regional heritability), estimate selection on sociality, and
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environments. This particular project focusses on chronic infection of halophilic viruses. We offer an excellent opportunity to engage into an exciting PhD project that combines microbiology, genetic, microscopy
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factors that provided novel insights in this repair pathway (van Toorn et al., Molecular Cell, 2022, Geijer et al., Nature Cell Biology, 2021, Tresini et al. Nature, 2015, Schwertman et al. Nature Genetics