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step in eukaryotic gene expression, ensuring that mature transcripts are delivered from the nucleus to the cytoplasm for translation. Multiple challenges are faced in this process: How are mRNAs
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) are important mediators of most cellular processes. Understanding how proteins interact with each other, ideally at structural resolution, is key in understanding molecular processes, how disease mutations would
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translocases have been shown to regulate R-loop levels in cells. In recent years, R-loops have been recognized as a major cell-intrinsic source of genomic instability, and dysregulation of R-loop processing is
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longer-term immune responses. Specifically, they play key roles in pathogen recognition, antigen uptake, processing and presentation, but also contribute to tissue homeostasis, tolerance to commensal