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decide the fate of their RNAs - whether to translate, store, or degrade them. Using biochemical reconstitution, fluorescent labeling, and single-molecule imaging, you will explore how molecular machines
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FUNDACIO INSTITUT D'INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL | Spain | 2 months ago
, immunocytochemistry. Experience with in vivo imaging systems such as echocardiography, electrocardiography, micro-CT, MRI, luminescence and fluorescence for tissues or small animal models will be valued
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: Development of chemical biology techniques for fluorescent labeling and imaging of biomolecules and cells. Chemical biology researches on analysis and control of chemical modification, interaction
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of paraspeckle assembly and dysregulation in human disease, such as neurodegeneration and viral infections. However, so far, structural studies of paraspeckles have been limited to fluorescent imaging approaches
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live-cell imaging in collaboration with the Advanced Microscopy platform at the Francis Crick Institute, as well as transcriptomic and proteomic approaches to define the downstream pathways controlled by
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model development. -Proficiency in molecular and cellular biology techniques (e.g., DNA/RNA extraction, flow cytometry, histology, fluorescence imaging). -Proven record of first-author publications in
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phenotype using histology image, etc. in candidate experimental animals with different treatments. The candidate will perform histological and immunohistochemical and confocal fluorescence studies in
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Sciences Institute, including a Leica Stellaris cryo-confocal, an Aquilos2, a Titan Krios G4i (with K3, Bioquantum imaging filter, and phase plate), and an Oxford Nanoimager. You will report directly to Drs
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-resolution imaging and state-of-the art biophysical techniques such as spinning disk confocal fluorescence microscopy and adaptive optical tweezers. A small amount of time will be devoted to lab organization
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reconstitution, cell biology, and fluorescence microscopy imaging tools, we aim to uncover how protein-membrane interactions promote membrane microdomain formation and how these structures respond to external